Newest and Lowest Rated Papers
Comprehensive Identification of Human Cell Type Chromatin Activity-Specific and Cell Type Expression-Specific MicroRNAs - PMC
Yu Han, Yuan Zhou
pmc.ncbi.nlm.nih.gov
MicroRNAs (miRNAs) regulate multiple transcripts and thus shape the expression landscape of a cell. Information about miRNA expression and distribution across cell types is crucial for the understanding of miRNAs’ functions and their translational ...
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View paper →Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b
Rossi, Riccardo L, Rossetti, Grazisa, Wenandy, Lynn, Curti, Serena, Ripamonti, Anna, Bonnal, Raoul J P, Birolo, Roberto Sciarretta, Moro, Monica, Crosti, Maria C, Gruarin, Paola, Maglie, Stefano, Marabita, Francesco, Mascheroni, Debora, Parente, Valeria, Comelli, Mario, Trabucchi, Emilio, De Francesco, Raffaele, Geginat, Jens, Abrignani, Sergio, Pagani, Massimiliano
Nature·2011
MicroRNAs are post-transcriptional regulators of gene expression. Pagani and colleagues identify specific microRNA signatures and their target genes in various human lymphoid subsets. MicroRNAs are small noncoding RNAs that regulate gene expression post-transcriptionally. Here we applied microRNA profiling to 17 human lymphocyte subsets to identify microRNA signatures that were distinct among various subsets and different from those of mouse lymphocytes. One of the signature microRNAs of naive CD4+ T cells, miR-125b, regulated the expression of genes encoding molecules involved in T cell differentiation, including IFNG, IL2RB, IL10RA and PRDM1. The expression of synthetic miR-125b and lentiviral vectors encoding the precursor to miR-125b in naive lymphocytes inhibited differentiation to effector cells. Our data provide an 'atlas' of microRNA expression in human lymphocytes, define subset-specific signatures and their target genes and indicate that the naive state of T cells is enforced by microRNA.
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View paper →Historic Patterns of Intervention: U.S. Relations with Latin America
David G. Haglund, J. Michael Hogan, Mark T. Gilderhus, John F. Bratzel, Karl Bermann, Harold Molineu
Latin American Research Review·1988
No abstract available
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View paper →A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing - PMC
Pablo Landgraf, Mirabela Rusu, Robert Sheridan, Alain Sewer, Nicola Iovino, Alexei Aravin, Sébastien Pfeffer, Amanda Rice, Alice O Kamphorst, Markus Landthaler, Carolina Lin, Nicholas D Socci, Leandro Hermida, Valerio Fulci, Sabina Chiaretti, Robin Foà, Julia Schliwka, Uta Fuchs, Astrid Novosel, Roman-Ulrich Müller, Bernhard Schermer, Ute Bissels, Jason Inman, Quang Phan, Minchen Chien, David B Weir, Ruchi Choksi, Gabriella De Vita, Daniela Frezzetti, Hans-Ingo Trompeter, Veit Hornung, Grace Teng, Gunther Hartmann, Miklos Palkovits, Roberto Di Lauro, Peter Wernet, Giuseppe Macino, Charles E Rogler, James W Nagle, Jingyue Ju, F Nina Papavasiliou, Thomas Benzing, Peter Lichter, Wayne Tam, Michael J Brownstein, Andreas Bosio, Arndt Borkhardt, James J Russo, Chris Sander, Mihaela Zavolan, Thomas Tuschl
pmc.ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are small non-coding regulatory RNAs that reduce stability and/or translation of fully or partially sequence-complementary target mRNAs. In order to identify miRNAs and to assess their expression patterns, we sequenced over 250 ...
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View paper →CDT1 induces the formation of polyploid giant cancer cells and promotes centrosome amplification through the PLK4/SASS6 axis
Unknown Author
sciencedirect.com·2025
No abstract available
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View paper →Identification of hundreds of conserved and nonconserved human microRNAs
Bentwich, Isaac, Avniel, Amir, Karov, Yael, Aharonov, Ranit, Gilad, Shlomit, Barad, Omer, Barzilai, Adi, Einat, Paz, Einav, Uri, Meiri, Eti, Sharon, Eilon, Spector, Yael, Bentwich, Zvi
Nature·2005
MicroRNAs are noncoding RNAs of ∼22 nucleotides that suppress translation of target genes by binding to their mRNA and thus have a central role in gene regulation in health and disease1,2,3,4,5. To date, 222 human microRNAs have been identified6, 86 by random cloning and sequencing, 43 by computational approaches and the rest as putative microRNAs homologous to microRNAs in other species. To prove our hypothesis that the total number of microRNAs may be much larger and that several have emerged only in primates, we developed an integrative approach combining bioinformatic predictions with microarray analysis and sequence-directed cloning. Here we report the use of this approach to clone and sequence 89 new human microRNAs (nearly doubling the current number of sequenced human microRNAs), 53 of which are not conserved beyond primates. These findings suggest that the total number of human microRNAs is at least 800.
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View paper →MicroRNA transcriptomes of distinct human NK cell populations identify miR-362-5p as an essential regulator of NK cell function | Scientific Reports
Ni, Fang, Guo, Chuang, Sun, Rui, Fu, Binqing, Yang, Yue, Wu, Lele, Ren, Sitong, Tian, Zhigang, Wei, Haiming
Nature·2015
Natural killer (NK) cells are critical effectors in the immune response against malignancy and infection and microRNAs (miRNAs) play important roles in NK cell biology. Here we examined miRNA profiles of human NK cells from different cell compartments (peripheral blood, cord blood and uterine deciduas) and of NKT and T cells from peripheral blood and we identified a novel miRNA, miR-362-5p, that is highly expressed in human peripheral blood NK (pNK) cells. We also demonstrated that CYLD, a negative regulator of NF-κB signaling, was a target of miR-362-5p in NK cells. Furthermore, we showed that the over-expression of miR-362-5p enhanced the expression of IFN-γ, perforin, granzyme-B and CD107a in human primary NK cells and we found that silencing CYLD with a small interfering RNA (siRNA) mirrored the effect of miR-362-5p over-expression. In contrast, the inhibition of miR-362-5p had the opposite effect in NK cells, which was abrogated by CYLD siRNA, suggesting that miR-362-5p promotes NK-cell function, at least in part, by the down-regulation of CYLD. These results provide a resource for studying the roles of miRNAs in human NK cell biology and contribute to a better understanding of the physiologic significance of miRNAs in the regulation of NK cell function.
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View paper →The astrocytic ensemble acts as a multiday trace to stabilize memory
Ken-ichi Dewa, Kodai Kaseda, Aoi Kuwahara, Hideaki Kubotera, Ayato Yamasaki, Natsumi Awata, Atsuko Komori, Mika A. Holtz, Atsushi Kasai, Henrik Skibbe, Norio Takata, Tatsushi Yokoyama, Makoto Tsuda, Genri Numata, Shun Nakamura, Eiki Takimoto, Masayuki Sakamoto, Minako Ito, Takahiro Masuda, Jun Nagai
Nature·2025·7 citations
<jats:title>Abstract</jats:title>
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Recalled memories become transiently labile and require stabilization
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. The mechanism for stabilizing memories of survival-critical experiences, which are often emotionally salient and repeated, remains unclear
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. Here we identify an astrocytic ensemble that is transcriptionally primed by emotional experience and functionally triggered by repeated experience to stabilize labile memory. Using a novel brain-wide
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tagging and imaging method, we found that astrocytic
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ensembles were preferentially recruited in regions with neuronal engrams
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and were more widespread during fear recall than during conditioning. We established the induction mechanism of the astrocytic ensemble, which involves two steps: (1) an initial fear experience that induces day-long, slow astrocytic state changes with noradrenaline receptor upregulation; and (2) enhanced noradrenaline responses during recall, a repeated experience, enabling astrocytes to integrate coincident signals from local engrams and long-range noradrenergic projections, which induce secondary astrocytic state changes, including the upregulation of
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and the neuromodulatory molecule IGFBP2. Pharmacological and genetic perturbation of the astrocytic ensemble signalling modulate engrams, and memory stability and precision. The astrocytic ensemble thus acts as a multiday trace in a subset of astrocytes after experience-dependent neural activity, which are eligible to capture future repeated experiences for stabilizing memories.
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View paper →Topological Data Analysis
Larry Wasserman
arXiv·2016
Topological Data Analysis (TDA) can broadly be described as a collection of data analysis methods that find structure in data. This includes: clustering, manifold estimation, nonlinear dimension reduction, mode estimation, ridge estimation and persistent homology. This paper reviews some of these methods.
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View paper →Antibiotic Resistance Genes in the Human-Impacted Environment: A One Health Perspective
James M. TIEDJE, Fang WANG, Célia M. MANAIA, Marko VIRTA, Hongjie SHENG, Liping MA, Tong ZHANG, Edward TOPP
Pedosphere·2019·135 citations
No abstract available
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View paper →SIMONE DE BEAUVOIR AND THE WOMEN'S MOVEMENT IN FRANCE: AN EYE-WITNESS ACCOUNT
CLAUDINE MONTEIL
Simone de Beauvoir Studies·1997
No abstract available
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