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ABSTRACT The scarcity of fresh water in the Mediterranean region necessitates the search for halotolerant agents of biological control of plant diseases that can be applied in arid-zone agriculture irrigated with saline water. Among 29 Trichoderma strains previously isolated from Mediterranean Psammocinia sp. sponges, the greatest number of isolates belong to the Trichoderma longibrachiatum - Hypocrea orientalis species pair (9), H. atroviridis/T. atroviride (9), and T. harzianum species complex (7), all of which are known for high mycoparasitic potential. In addition, one isolate of T. asperelloides and two putative new species, Trichoderma sp. O.Y. 14707 and O.Y. 2407, from Longibrachiatum and Strictipilosa clades, respectively, have been identified. In vitro salinity assays showed that the ability to tolerate increasing osmotic pressure (halotolerance) is a strain- or clade-specific property rather than a feature of a species. Only a few isolates were found to be sensitive to increased salinity, while others either were halotolerant or even demonstrated improved growth in increasingly saline conditions. In vitro antibiosis assays revealed strong antagonistic activity toward phytopathogens due to the production of both soluble and volatile metabolites. Two marine-derived Trichoderma isolates, identified as T. atroviride and T. asperelloides , respectively, effectively reduced Rhizoctonia solani damping-off disease on beans and also induced defense responses in cucumber seedlings against Pseudomonas syringae pv. lachrimans. This is the first inclusive evaluation of marine fungi as potential biocontrol agents.

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Why Philosophers Should Care About Computational Complexity

Scott Aaronson

arXiv·2011

One might think that, once we know something is computable, how efficiently it can be computed is a practical question with little further philosophical importance. In this essay, I offer a detailed case that one would be wrong. In particular, I argue that computational complexity theory -- the field that studies the resources (such as time, space, and randomness) needed to solve computational problems -- leads to new perspectives on the nature of mathematical knowledge, the strong AI debate, computationalism, the problem of logical omniscience, Hume's problem of induction, Goodman's grue riddle, the foundations of quantum mechanics, economic rationality, closed timelike curves, and several other topics of philosophical interest. I end by discussing aspects of complexity theory itself that could benefit from philosophical analysis.

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Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection.

John R Teijaro, Kevin B Walsh, Stuart Cahalan, Daniel M Fremgen, Edward Roberts, Fiona Scott, Esther Martinborough, Robert Peach, Michael B A Oldstone, Hugh Rosen

Cell·2011

Cytokine storm during viral infection is a prospective predictor of morbidity and mortality, yet the cellular sources remain undefined. Here, using genetic and chemical tools to probe functions of the S1P(1) receptor, we elucidate cellular and signaling mechanisms that are important in initiating cytokine storm. Whereas S1P(1) receptor is expressed on endothelial cells and lymphocytes within lung tissue, S1P(1) agonism suppresses cytokines and innate immune cell recruitment in wild-type and lymphocyte-deficient mice, identifying endothelial cells as central regulators of cytokine storm. Furthermore, our data reveal immune cell infiltration and cytokine production as distinct events that are both orchestrated by endothelial cells. Moreover, we demonstrate that suppression of early innate immune responses through S1P(1) signaling results in reduced mortality during infection with a human pathogenic strain of influenza virus. Modulation of endothelium with a specific agonist suggests that diseases in which amplification of cytokine storm is a significant pathological component could be chemically tractable.

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In situ ellipsometry study of atomic hydrogen etching of extreme ultraviolet induced carbon layers

Juequan Chen, Eric Louis, Rob Harmsen, Tim Tsarfati, Herbert Wormeester, Maarten van Kampen, Willem van Schaik, Robbert van de Kruijs, Fred Bijkerk

Applied Surface Science·2011·24 citations

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Jewish Problems

Tanya Khovanova, Alexey Radul

arXiv·2011

This is a special collection of problems that were given to select applicants during oral entrance exams to the math department of Moscow State University. These problems were designed to prevent Jews and other undesirables from getting a passing grade. Among problems that were used by the department to blackball unwanted candidate students, these problems are distinguished by having a simple solution that is difficult to find. Using problems with a simple solution protected the administration from extra complaints and appeals. This collection therefore has mathematical as well as historical value.

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The structure of approximate groups

Emmanuel Breuillard, Ben Green, Terence Tao

arXiv·2011

Let K >= 1 be a parameter. A K-approximate group is a finite set A in a (local) group which contains the identity, is symmetric, and such that A^2 is covered by K left translates of A. The main result of this paper is a qualitative description of approximate groups as being essentially finite-by-nilpotent, answering a conjecture of H. Helfgott and E. Lindenstrauss. This may be viewed as a generalisation of the Freiman-Ruzsa theorem on sets of small doubling in the integers to arbitrary groups. We begin by establishing a correspondence principle between approximate groups and locally compact (local) groups that allows us to recover many results recently established in a fundamental paper of Hrushovski. In particular we establish that approximate groups can be approximately modeled by Lie groups. To prove our main theorem we apply some additional arguments essentially due to Gleason. These arose in the solution of Hilbert's fifth problem in the 1950s. Applications of our main theorem include a finitary refinement of Gromov's theorem, as well as a generalized Margulis lemma conjectured by Gromov and a result on the virtual nilpotence of the fundamental group of Ricci almost nonnegatively curved manifolds.

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