Comparative genome sequence analysis underscores mycoparasitism as the ancestral life style of Trichoderma
Christian P Kubicek, Alfredo Herrera-Estrella, Verena Seidl-Seiboth, Diego A Martinez, Irina S Druzhinina, Michael Thon, Susanne Zeilinger, Sergio Casas-Flores, Benjamin A Horwitz, Prasun K Mukherjee, Mala Mukherjee, László Kredics, Luis D Alcaraz, Andrea Aerts, Zsuzsanna Antal, Lea Atanasova, Mayte G Cervantes-Badillo, Jean Challacombe, Olga Chertkov, Kevin McCluskey, Fanny Coulpier, Nandan Deshpande, Hans von Döhren, Daniel J Ebbole, Edgardo U Esquivel-Naranjo, Erzsébet Fekete, Michel Flipphi, Fabian Glaser, Elida Y Gómez-Rodríguez, Sabine Gruber, Cliff Han, Bernard Henrissat, Rosa Hermosa, Miguel Hernández-Oñate, Levente Karaffa, Idit Kosti, Stéphane Le Crom, Erika Lindquist, Susan Lucas, Mette Lübeck, Peter S Lübeck, Antoine Margeot, Benjamin Metz, Monica Misra, Helena Nevalainen, Markus Omann, Nicolle Packer, Giancarlo Perrone, Edith E Uresti-Rivera, Asaf Salamov, Monika Schmoll, Bernhard Seiboth, Harris Shapiro, Serenella Sukno, Juan Antonio Tamayo-Ramos, Doris Tisch, Aric Wiest, Heather H Wilkinson, Michael Zhang, Pedro M Coutinho, Charles M Kenerley, Enrique Monte, Scott E Baker, Igor V Grigoriev
Genome Biology·2011·604 citations
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Mycoparasitism, a lifestyle where one fungus is parasitic on another fungus, has special relevance when the prey is a plant pathogen, providing a strategy for biological control of pests for plant protection. Probably, the most studied biocontrol agents are species of the genus<jats:italic>Hypocrea</jats:italic>/<jats:italic>Trichoderma</jats:italic>.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Here we report an analysis of the genome sequences of the two biocontrol species<jats:italic>Trichoderma atroviride</jats:italic>(teleomorph<jats:italic>Hypocrea atroviridis</jats:italic>) and<jats:italic>Trichoderma virens</jats:italic>(formerly<jats:italic>Gliocladium virens</jats:italic>, teleomorph<jats:italic>Hypocrea virens</jats:italic>), and a comparison with<jats:italic>Trichoderma reesei</jats:italic>(teleomorph<jats:italic>Hypocrea jecorina</jats:italic>). These three<jats:italic>Trichoderma</jats:italic>species display a remarkable conservation of gene order (78 to 96%), and a lack of active mobile elements probably due to repeat-induced point mutation. Several gene families are expanded in the two mycoparasitic species relative to<jats:italic>T. reesei</jats:italic>or other ascomycetes, and are overrepresented in non-syntenic genome regions. A phylogenetic analysis shows that<jats:italic>T. reesei</jats:italic>and<jats:italic>T. virens</jats:italic>are derived relative to<jats:italic>T. atroviride</jats:italic>. The mycoparasitism-specific genes thus arose in a common<jats:italic>Trichoderma</jats:italic>ancestor but were subsequently lost in<jats:italic>T. reesei</jats:italic>.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The data offer a better understanding of mycoparasitism, and thus enforce the development of improved biocontrol strains for efficient and environmentally friendly protection of plants.</jats:p></jats:sec>