Newest and Highest Rated Papers
Pluralistic: The Reverse-Centaur’s Guide to Criticizing AI (05 Dec 2025) – Pluralistic: Daily links from Cory Doctorow
Cory Doctorow
pluralistic.net·2025
No abstract available
★ 4.0 (1)
View paper →Efficacy of liposomal amphotericin B for treating post-kala-azar dermal leishmaniasis (PKDL): A systematic review and single-arm meta-analysis
Deivyd Vieira Silva Cavalcante, Lilia Maria Lima de Oliveira, Noor Husain, Beatriz Ximenes Mendes, Ana Clara Felix de Farias Santos, Luciana Borrigueiro, Lyria de Oliveira Rosa, Christian Ndikuryayo, Sarah Soares Amorim, Lalit Mohan, Fabiana Castro Porto Silva Lopes
Diagnostic Microbiology and Infectious Disease·2025
Background
Post-kala-azar dermal leishmaniasis (PKDL) is a skin condition that can become a complication in about 15 % of patients who have had kala-azar. Despite its significance, treatment options for PKDL are still limited. This systematic review and meta-analysis aim to evaluate the efficacy of amphotericin B for this condition.
Methods
PubMed, Embase, Cochrane, and Web of Science databases were searched for randomized controlled trials (RCTs) that reported the efficacy of Liposomal Amphotericin B in the treatment of PKDL. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Events per 100 observations with 95 % confidence intervals were performed for outcomes.
Results
Nine studies with 639 patients were included, the treatment durations ranging from 7 to 60 days. The mean age ranged from 9.2 to 31.0 years, and 359 patients were male. The PKDL treatment with liposomal amphotericin B resulted in a cure rate of 91.36 % (95 % CI: 76.60-97.15). However, a relapse was observed in 11.42 % (95 % CI: 6.20-20.8) of patients. Adverse events were common, with hepatic enzyme elevation (ALT/AST) being the most frequent (61.75 %; 95 % CI: 21.81–90.33), followed by fever in 29.93 % of cases (95 % CI: 5.09–77.30). Among the more serious side effects, decreased serum potassium was observed in 19.27 % (95 % CI: 3.84–58.82), and increased serum creatinine, indicative of nephrotoxicity, occurred in 15.08 % (95 % CI: 3.97–43.27). Nausea or vomiting, although less severe, affected 12.36 % of patients (95 % CI: 4.81–28.25).
Conclusions
These findings highlight that while liposomal amphotericin B is a potent therapeutic option for PKDL, its administration requires careful management and clinical vigilance to optimize outcomes and minimize risks.
★ 4.0 (2)
View paper →Feminist theory and the problem of misogyny
Samantha Pinson Wrisley
Feminist Theory·2021·20 citations
<jats:p> Feminist theory, broadly construed, lacks a comprehensive theory of misogyny. While there has been a great deal of feminist work dedicated to analysing the social, cultural, political, and institutional effects of misogyny, the ancillary theories of misogyny these analyses produce are only ever partial, fragmented, vague or conceptually inconsistent. This article engages and critiques these theories by focusing on three separate but related issues within existing feminist scholarship on misogyny: the conflation of misogyny with sexism, the elision of misogyny's affective elements and the supplanting of misogyny with gendered violence. Through my identification and critique of these issues, I argue that misogyny should be understood as a profoundly complicated and emotional social dynamic. Moreover, I argue that to attempt to cleanse misogyny of its affective/emotional complexity or conflate misogyny with sexism and/or violence is to rob theorists of possible loci of apprehension and intervention. My hope is that this article will stimulate feminist theorists to work collectively towards a more comprehensive feminist understanding of misogyny – one that grapples with the interpersonal and affective complexities of how misogyny emerges, circulates and self-perpetuates. </jats:p>
★ 4.0 (1)
View paper →Black Actresses Are Carrying One Battle After Another
Angelica Jade Bastién
Vulture·2025
Teyana Taylor, Chase Infiniti, and Regina Hall propel Paul Thomas Anderson’s most conflicted ideas in ‘One Battle After Another.’ As Angelica Jade Bastién writes, ‘It’s thrilling to watch them embody what his script can only loosely hold.’
★ 4.0 (1)
View paper →Everyone Is Beautiful and No One Is Horny - Blood Knife
Blood Knife
Blood Knife·2021
The human body has become a strange contradiction at the heart of the modern blockbuster. Sexy, yes. But sexual? No.
★ 4.0 (1)
View paper →Introduction: How AZT Changed Aztlán. Archiving an Epidemic: Art, AIDS, and the Queer Chicanx Avant-Garde.
Robb Hernández
Archiving an Epidemic·2020
No abstract available
★ 4.0 (1)
View paper →Predictive Modeling of Virus Inactivation by UV
Nicole C. Rockey, James B. Henderson, Kaitlyn Chin, Lutgarde Raskin, Krista R. Wigginton
Environmental Science & Technology·2021·40 citations
No abstract available
★ 4.0 (1)
View paper →Shack
Larry Brown
2001
In the Mississippi Hill Country, the novelist built a writer’s cabin beneath tall pines. Little did he know that, beam by beam, he was building it for others
★ 4.0 (1)
View paper →Bank Funding Costs What Are They What Determines Them And Why Do They Matter
Beau, Emily; Hill, John; Hussain, Tanveer; Nixon, Dan
Bank of England
No abstract available
★ 4.0 (1)
View paper →Supportive marriages may shape appetite control through oxytocin and the brain–gut axis
Vijay Kumar Malesu
News-Medical·2025
Supportive marital relationships are associated with lower BMI, fewer food addiction symptoms, higher oxytocin, stronger frontal brain responses to food cues, and favorable gut tryptophan metabolites.
These coordinated social, neural, hormonal, and gut pathways suggest a plausible biological link between emotional support and healthier eating regulation.
★ 4.0 (2)
View paper →