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The mediating role of anxiety in the relationship between misophonia and quality of life: findings from the validated Turkish version of MisoQuest

Ezgi Ay, Mert Huviyetli, Eda Çakmak

Frontiers in Psychology·2024·6 citations

IntroductionMisophonia is a disorder characterized by decreased tolerance to certain sounds or their associated stimuli, and many measurement tools have been developed for its diagnosis and evaluation. The aims of the current study were to develop the Turkish version of MisoQuest, a fully validated misophonia questionnaire, to evaluate the relationships between misophonia, anxiety, and quality of life, and to examine the mediating role of anxiety in the relationship between misophonia and quality of life.MethodsThe reliability of the Turkish version of MisoQuest was conducted using data from 548 participants (Mean age = 28.06 ± 9.36). Then, the relationships between misophonia, anxiety, and quality of life were evaluated in a separate sample of 117 participants (Mean age = 25.50 ± 6.31) using the State–Trait Anxiety Inventory (STAI) and the Short Form 36 (SF-36) questionnaire.ResultsThe results showed that the Turkish version of MisoQuest has good psychometric properties. Close-to-moderate positive correlations were found between misophonia and anxiety, and weak negative correlations were found between misophonia and quality of life. Anxiety mediated the relationships between misophonia and quality of life.DiscussionThese results emphasize that misophonia may be an important problem affecting people’s quality of life and reveal the mediating role of anxiety on this effect.

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Prevalence, phenomenology, and impact of misophonia in a nationally representative sample of U.S. adults.

Laura J. Dixon, Mary J. Schadegg, Heather L. Clark, Carey J. Sevier, Sara M. Witcraft

Journal of Psychopathology and Clinical Science·2024·16 citations

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Measuring Misophonia: Assessing the Psychometric Properties of the MisoQuest and Its Ability to Predict Cognitive Impacts of Triggering Sounds

Kate E. Raymond, Blake E. Butler

Journal of Clinical Psychology·2025

ABSTRACT Objectives Misophonia is characterized by an aversion to specific sounds, such as chewing and breathing. These “trigger” sounds can elicit negative emotional reactions, physiological stress, and cognitive impairments in people with misophonia. Despite its impact, misophonia lacks formal diagnostic classification, largely due to challenges in conceptualization and assessment. One of the few psychometrically robust self‐report measures for misophonia (the MisoQuest) was originally developed and evaluated in Polish. The current study evaluated the utility of the English language version of the MisoQuest, including assessment of its criterion validity using cognitive performance as an outcome. Methods A total of 139 participants (44 people with misophonia and 95 controls) completed the MisoQuest, the Selective Sound Sensitivity Syndrome Scale (S‐Five), the Generalized Anxiety Disorders Scale, and the Sensory Hypersensitivity Scale. Participants then completed either a Stroop task or reading comprehension task in the presence/absence of triggering sounds. A subset of participants retook the MisoQuest after 5 weeks. Results The MisoQuest showed excellent internal consistency and strong test‐retest reliability. Additionally, MisoQuest scores strongly correlated with S‐Five scores, supporting convergent validity, and moderately correlated with measures of generalized anxiety and sensory hypersensitivity, indicating some overlap while supporting discriminant validity. Higher MisoQuest scores predicted poorer reading comprehension performance when trigger sounds were present, supporting criterion validity. However, MisoQuest scores showed no significant relationship with Stroop task performance. Conclusion These findings support the MisoQuest as a reliable and useful measure of misophonia in English‐speaking individuals and suggest its scores may relate to clinically relevant outcomes.

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Evaluation of Attention and Verbal Memory Functions of Individuals with Misophonia

Davut Aslan, Hasan Demirci, Senem Kurt-Dizdar, Ömer Akil Özer

Neuropsychiatric Investigation·2025

Objective: The aim of this study was to evaluate the attention and verbal memory performances of individuals with symptoms of misophonia.Methods: The study included 70 participants: 30 with misophonia and 40 controls without misophonia. The Depression Anxiety Stress Scale (DASS-21), Misophonia Questionnaire, Digit Span Test (DST), Verbal Fluency Test (VFT), Stroop Test (ST), and Verbal Memory Processes Scale (VMPS) were applied to the participants.Results: The depression, anxiety, and stress scores of the misophonia group were statistically significantly higher than the control group (P < .05). The misophonia group performed poorly compared with the control group on 2 tests assessing attention (semantic fluency and ST-number of incorrect) (P < .05). No difference was found between the groups in cognitive areas such as simple attention, working memory, phonetic fluency, and verbal memory.Conclusion: Misophonia has a limited effect on attention functions. This effect was not observed in verbal memory. More comprehensive studies are needed to determine the effects of misophonia on attention, and memory.Cite this article as: Aslan D, Demirci H, Kurt-Dizdar S, Özer OA. Evaluation of attention and verbal memory functions of individuals with misophonia. Neuropsychiatr Invest. 2025; 63, 0063, doi: 10.5152/NeuropsychiatricInvest.2025.24063.

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Preliminary validation of the Norwegian version of the Berlin Misophonia Questionnaire Revised (<scp>BMQ‐R‐NOR</scp>)

Eirin Krog, Andreas Falck, Guri Engernes Nielsen

Scandinavian Journal of Psychology·2024·1 citations

ObjectiveTo perform a psychometric evaluation of a Norwegian version of the Berlin Misophonia Questionnaire Revised (BMQ‐R‐NOR).DesignParticipants completed online versions of the self‐report questionnaire BMQ‐R‐NOR on two occasions and MQ‐NOR on one occasion. Convergent validity was assessed through Spearman's correlation between BMQ‐R‐NOR and MQ‐NOR. Internal consistency was evaluated with McDonald's omega and Cronbach's alpha. Test–retest reliability was evaluated using Cohen's weighted kappa and intraclass correlation.Study sample82 participants with self‐reported misophonia took part in the study at T1, and 53 of these participated at T2. However, only 41 of them were included in the test–retest analyses due to 12 participants being in treatment between T1 and T2.ResultsSubscales from the BMQ‐R‐NOR and MQ‐NOR were significantly positively correlated, indicating evidence of convergent validity (rs = 0.22*–0.74**). The BMQ‐R‐NOR showed overall good internal consistency (omega = 0.72–0.93; alpha = 0.70–0.93) and satisfactory test–retest reliability (ICC = 0.35–0.92).ConclusionThe psychometric properties of the BMQ‐R‐NOR are considered satisfactory. However, it is advised to exercise caution when using it until further comprehensive validation studies are conducted to ensure robustness and reliability in clinical practice.

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Review of multiple sclerosis: Epidemiology, etiology, pathophysiology, and treatment

Maha Haki, Haeder A. AL-Biati, Zahraa Salam Al-Tameemi, Inas Sami Ali, Hany A. Al-hussaniy

Medicine·2024·143 citations

Multiple sclerosis (MS) is a chronic autoimmune disease with demyelination, inflammation, neuronal loss, and gliosis (scarring). Our object to review MS pathophysiology causes and treatment. A Narrative Review article was conducted by searching on Google scholar, PubMed, Research Gate about relevant keywords we exclude any unique cases and case reports. The destruction of myelinated axons in the central nervous system reserves this brunt. This destruction is generated by immunogenic T cells that produce cytokines, copying a proinflammatory T helper cells1-mediated response. Autoreactive cluster of differentiation 4 + cells, particularly the T helper cells1 subtype, are activated outside the system after viral infections. T-helper cells (cluster of differentiation 4+) are the leading initiators of MS myelin destruction. The treatment plan for individuals with MS includes managing acute episodes, using disease-modifying agents to decrease MS biological function of MS, and providing symptom relief. Management of spasticity requires physiotherapy, prescription of initial drugs such as baclofen or gabapentin, secondary drug options such as tizanidine or dantrolene, and third-line treatment such as benzodiazepines. To treat urinary incontinence some options include anticholinergic medications such as oxybutynin hydrochloride, tricyclic antidepressants (such as amitriptyline), and intermittent self-catheterization. When it comes to bowel problems, one can try to implement stool softeners and consume a high roughage diet. The review takes about MS causes Pathophysiology and examines current treatment strategies, emphasizing the advancements in disease-modifying therapies and symptomatic treatments. This comprehensive analysis enhances the understanding of MS and underscores the ongoing need for research to develop more effective treatments.

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Volunteering and Metabolic Syndrome and Diabetes in Black Adolescents From Low-Income Families

Edith Chen, Sarah O. Germer, Hee Moon, Johanna Dezil, Robin Hayen, Tianyi Yu

JAMA Network Open·2026

Importance Disparities by race and socioeconomic status in cardiometabolic diseases are prevalent, and social determinants of health (SDOH) are significant contributors to these disparities. However, SDOH research often focuses on negative factors. Objective To examine associations of volunteering, a potentially positive SDOH, with metabolic syndrome and diabetes across 2 samples of Black adolescents from lower-income households, and to assess mediators of associations. Design, Setting, and Participants This cohort study used data from 2 studies. Study 1 was a cross-sectional study of Black adolescents (ages 14-19 years) in households with less than 2 times the poverty threshold from 2018 to 2022. Study 2 was a 14-year longitudinal study of Black adolescents (ages 11-20 years) from low-income families from 1994 to 2008. Data were analyzed from April 2024 to November 2025. Exposure Study 1 examined volunteering as a binary yes/no as well as volunteering frequency; study 2 examined volunteering from ages 12 to 18 years. Main Outcomes and Measures Study 1: metabolic syndrome (counts of the number of metabolic syndrome components above clinical cutoffs; composite z scores of each metabolic syndrome component). Study 2: diabetes diagnosis at age 29. Results Study 1 included 400 Black adolescents (256 [64.0%] female; mean [SD] age, 16.39 [1.56] years). Study 2 included 979 Black adolescents (570 [58.2%] female; mean [SD] age, 15.87 [1.71] years). In study 1, a higher frequency of volunteering was associated with a lower metabolic syndrome composite score ( b = −0.06; SE, 0.03; P = .03). Purpose in life, but not physical activity or depressive symptoms, statistically mediated associations between volunteering and metabolic syndrome. In study 2, participants who volunteered during adolescence had lower odds of adult diabetes (odds ratio, 0.48; 95% CI, 0.24 to 0.94; P = .03). Conclusions and Relevance These results suggest that encouraging adolescents to volunteer may represent a novel approach to improving cardiometabolic health earlier in life and in groups that have been historically marginalized. The notion that volunteering might help not only the recipients of volunteering efforts, but also the volunteers themselves, suggests the possibility of creating a 2-way street of benefits through a single activity that could promote health across groups while also strengthening the social fabric across communities.

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Collaborative Reasoner: Self-improving Social Agents with Synthetic Conversations

Ansong Ni, Ruta Desai, Yang Li, Xinjie Lei, Dong Wang, Ramya Raghavendra, Gargi Ghosh, Daniel Li, Asli Celikyilmaz

NeurIPS 2025

With increasingly more powerful large language models (LLMs) and LLM-based agents tackling an ever-growing list of tasks, we envision a future where numerous different LLM agents work seamlessly with other AI agents or humans facilitating everyday life in myriad ways from problem-solving to planning, knowledge gathering, and learning. To navigate through various scenarios in different social context, such LLM agents needs to possess collaborative skills, such as effective communication, theory-of-mind, and yet such skills are often ignored in the predominant single-turn evaluation of LLMs. Moreover, improving collaborative skills of these social agents would require large amount of conversational data, which are often expensive and less controllable thus hard to collect. To bridge the gap between problem-solving and social collaboration skills of LLMs, we present Collaborative Reasoner(Coral), a framework to evaluate and improve collaborative reasoning skills of language models. In particular, tasks and metrics in Coral necessitates agents to disagree to incorrect solutions, convince their partner of a correct solution, and ultimately agree as a team to commit to a final solution. Through the evaluation of Coral on 5 collaborative reasoning tasks, we show that current models cannot consistently utilize collaboration to achieve better task performance, and their social behaviors stemming from the current post-training process make them less desirable under collaborative scenarios. To improve collaborative reasoning capabilities of LLMs, we propose a self-improvement approach using synthetic interaction data, and to facilitate synthetic conversational data generation at scale, we built Matrix, a scalable and robust multi-agent communication framework. We leverage Coral and Matrix to synthesize supervised- and preference-finetuning data, based on the conversation turns that enable an agent to convince their partner on the correct solutions. Our self-improvement approach is shown to be effective on general, math, scientific and social reasoning tasks, yielding improvements up to 29.4% over chain-of-thought performance of an equivalent single agent LLM. We release code for Coral and Matrix for future research on collaborative social agents.

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Newest and Lowest Rated Papers

The mediating role of anxiety in the relationship between misophonia and quality of life: findings from the validated Turkish version of MisoQuest

Prevalence, phenomenology, and impact of misophonia in a nationally representative sample of U.S. adults.

Measuring Misophonia: Assessing the Psychometric Properties of the MisoQuest and Its Ability to Predict Cognitive Impacts of Triggering Sounds

Evaluation of Attention and Verbal Memory Functions of Individuals with Misophonia

Preliminary validation of the Norwegian version of the Berlin Misophonia Questionnaire Revised (<scp>BMQ‐R‐NOR</scp>)

Review of multiple sclerosis: Epidemiology, etiology, pathophysiology, and treatment

the power of knowing what you like

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Volunteering and Metabolic Syndrome and Diabetes in Black Adolescents From Low-Income Families

Collaborative Reasoner: Self-improving Social Agents with Synthetic Conversations

Psychometric Validation of the New Misophonia Screening List—Child and Youth and AMISOS-Y (Dutch Child- and Parent-Report Versions) for Assessing Misophonia in Youth