Newest Papers
The Problem With Treating VO₂max as a Longevity Score
Chris Masterjohn, PhD
Substack·2025
What the research actually shows about oxygen uptake, treadmill performance, and lifespan.
★ 5.0 (1)
View paper →FastCCC: a permutation-free framework for scalable, robust, and reference-based cell
Siyu Hou, Wenjing Ma, Xiang Zhou
Nature Communications·2025
No abstract available
★ 2.0 (1)
View paper →Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons
Jana Kroll, Uljana Kravčenko, Mohsen Sadeghi, Christoph A. Diebolder, Lia Ivanov, Małgorzata Lubas, Thiemo Sprink, Magdalena Schacherl, Mikhail Kudryashev, Christian Rosenmund
Nature Communications·2025
<jats:title>Abstract</jats:title>
<jats:p>Synaptic vesicle (SV) fusion is not only tightly coordinated but also happens at a millisecond timescale. Competing models for fusion initiation and propagation suggest tight docking and hemifusion of SVs or localized lipid rearrangements leading to tip-like membrane contacts. Yet, a direct nanoscale examination of the full SV fusion sequence has been lacking. Here, we establish a workflow for timed in situ cryo-electron tomography of optogenetically stimulated mouse neurons to capture the complete SV fusion sequence – from SV recruitment to fusion pore formation, opening and collapse – with near-native structural preservation. Notably, tethered SVs directly undergo fusion initiation via stalk formation, without preceding tight docking or SV flattening. The plasma membrane forms a minimal dimple during fusion initiation, contradicting preceding models that invoke strong membrane bending prior to fusion. In addition, we observe filaments linking fusing SVs to adjacent SVs, indicating a physical link between fusion and SV resupply.</jats:p>
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View paper →Characterizing Heterogeneity in Substance Use in a Large Sample of Canadian Adolescents: A Multilevel Latent Class Analysis
Sophie G. Coelho, Jeffrey D. Wardell, David B. Flora, Sergio Rueda, Sameer Imtiaz, Hayley A. Hamilton
International Journal of Mental Health and Addiction·2025
LCA) to delineate patterns of adolescent substance use, though rarely in settings where non-medical cannabis is legal and using multilevel analytic frameworks to account for clustering of students within schools. This study used multilevel LA to identify subgroups of high school students based on substance use patterns and correlates of subgroup membership in Ontario, Canada, where cannabis use is legal for adults ages 19 years and older. Data were from a representative sample of N= 7189 grades 9-12 students. Multilevel LCA with past-year use of alcohol, cannabis, nicotine, illegal drugs, and prescription drugs as latent class indicators identified no/low use (68.99%), moderate alcohol use and infrequent cannabis use (15.73%), and polysubstance use (15.28%) student-level latent classes, which were differentiated by sociodemographic, academic, and health-related factors. In revealing heterogeneity in adolescent substance use patterns and their risk factors, findings underscore the importance of tailored interventions for substance-related harms among adolescents.
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View paper →Extremadura. Las grietas en el patio trasero - Contracultura
Colaboraciones
Contracultura·2025
No abstract available
★ 3.0 (1)
View paper →Regulatory element modules as universal features for single
Chrysania Lim, Javen Tan Yih Ruay, Tim Stuart
2025
<jats:p>Single-cell chromatin accessibility data provide important insights into the activity of DNA regulatory elements in health and disease. However, the analysis of these data is made challenging by the lack of a common set of features for use in downstream analysis. This results in individual studies quantifying dataset-specific peak regions that cannot be directly compared to other studies. To address this challenge, we developed a comprehensive set of DNA regulatory element modules (REMO) for the human genome. Here we show how REMO can be applied to single-cell chromatin data to better separate cell states in a low-dimensional space compared to peak matrix quantification, greatly improve the scalability of dimension reduction steps, and enable automated annotation of cell types. This is accompanied by new memory-efficient and scalable software for the quantification of single-cell chromatin accessibility data.</jats:p>
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View paper →Replication of the Auditing Game Model Organism
Abhay Sheshadri, Rohan Gupta, Kei Nishimura-Gasparian, Rowan Wang, Johannes Treutlein Sam Marks
Anthropic Blog·2025
No abstract available
★ 4.0 (1)
View paper →The Emerging Market for Intelligence: Pricing, Supply, and Demand for LLMs
Unknown Author
2025
No abstract available
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View paper →RL Environments and the Hierarchy of Agentic Capabilities
Unknown Author
surgehq.ai·2025
No abstract available
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View paper →COMIC: A couple's therapist says you can break these relationship rules : NPR
Manoush Zomorodi, James Delahoussaye, Fiona Geiran, LA Johnson, Sanaz Meshkinpour, Katie Monteleone
NPR·2025
Is it a red flag if a couple has separate beds? What about separate bank accounts? Therapist Stephanie R. Yates-Anyabwile says ignoring relationship norms can actually make a partnership stronger.
★ 4.3 (3)
View paper →Balthazar, 1997 - The Paris Review
The Paris Review
Substack·2025
By Heather Bursch
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