TORC1 inhibition enhances immune function and reduces infections in the elderly

Joan B. Mannick, Melody Morris, Hans-Ulrich P. Hockey, Guglielmo Roma, Martin Beibel, Kenneth Kulmatycki, Mollie Watkins, Tea Shavlakadze, Weihua Zhou, Dean Quinn, David J. Glass, Lloyd B. Klickstein

Science Translational Medicine7/11/2018·DOI·Read paper

Abstract

Treating elderly subjects with two low-dose mTOR inhibitors that selectively block TORC1 led to a decrease in infection rates.

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