miRNA modules for precise, tunable control of gene expression - PMC

Rongrong Du, Michael J Flynn, Karan Mahe, Monique Honsa, Bo Gu, Dongyang Li, Sean E McGeary, Viviana Gradinaru, Ralf Jungmann, Michael B Elowitz

pmc.ncbi.nlm.nih.gov·Read paper

Abstract

Accurate control of transgene expression is important for research and therapy but challenging to achieve in most settings. miRNA-based regulatory circuits can be incorporated within transgenes for improved control. However, the design principles, ...

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