CD28-mediated linear and parallel costimulatory signaling cooperatively regulate CAR-T cell functions via CAR-CD28 microclusters - PMC

Tetsushi Nishikawa, Arata Takeuchi, Hiroaki Machiyama, Ei Wakamatsu, Hitoshi Nishijima, Masae Furuhata, Hiroko Toyota, Wataru Nishi, Ryohei Matsushima, Yosuke Yoshida, Kazutoshi Harada, Tadashi Yokosuka

pmc.ncbi.nlm.nih.gov·Read paper

Abstract

Various improvements have been made to chimeric antigen receptor (CAR)-T cells to enhance their antitumor effects and expand their indications to various cancer types. Although second-generation CARs directly induce second signals in a linear ...

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