Clinical Proof-of-Concept of a Non-Gene Editing Technology Using miRNA-Based shRNA to Engineer Allogeneic CAR T

Caroline Lonez, Jennifer Bolsée, Fanny Huberty, Thuy Nguyen, Céline Jacques-Hespel, Sebastien Anguille, Anne Flament, Eytan Breman

pmc.ncbi.nlm.nih.gov·Read paper

Abstract

With the success of chimeric antigen receptor (CAR) T-cell therapy in B-cell malignancies, efforts are being made to extend this therapy to other malignancies and broader patient populations. However, limitations associated with the time-consuming ...

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