Many chronic neurological, psychiatric and interface disorders can be understood as conditions where maladaptive homeostatic set points become entrenched, driving pathological states that resist spontaneous resolution. This paper proposes a novel conceptual framework, the therapeutic reset, which unifies diverse interventions that transiently disrupt pathological equilibria, thereby leveraging the intrinsic plasticity of biological systems to facilitate recalibration toward healthier set points. Drawing insights from active inference, dynamical systems theory and nested somatic collective intelligences, we illustrate how treatments such as electroconvulsive therapy, psychedelics, inflammatory perturbations and anaesthetic interventions create brief periods of heightened plasticity.
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